My overall aims are to improve outcomes for cancer patients and contribute to a dynamic translational and clinical research community. As a physician–scientist, I have longstanding experience in the clinical application of novel immunotherapies for the treatment of melanoma.
I have led numerous Phase I and II clinical trials across a broad portfolio of clinical and translational projects involving cytokines, peptide and protein vaccines, as well as targeted therapies including development of BRAF and MEK inhibitors. Over 20 years I have developed integrated clinical and laboratory teams focused on understanding immune responses against cancer and exploring new cancer therapies based on this knowledge. More recently, new insights into tumor resistance have shown that it is also critical to understand the biology of cancer plasticity to counter the mechanisms that underpin escape from immune control. My research brings these elements together with the intention of achieving greater clinical benefit.
My investigations and collaborations have resulted in more than 150 clinical and translational publications with a focus on melanoma cell biology and immunology, many invited reviews and eight patents. In addition to my clinical and research interests, I am actively involved in training and mentoring of Medical Oncology Advanced Trainees, Clinical Research Fellows, postdoctorals and postgraduate research students.
Member, Ludwig Institute for Cancer Research
Medical Director and Head of Cancer Immunobiology Laboratory, Olivia Newton-John Cancer Research Institute
Professor, School of Cancer Medicine, La Trobe University
Professor, University of Melbourne, Department of Medicine
Medical Director, Cancer and Neurosciences Clinical Service Unit, Austin Health
MBBS (Hons), University of Melbourne, Australia
Fellowship of the Royal Australasian College of Physicians, specialising in Medical Oncology
PhD, University of Melbourne. Thesis Title: Characterisation and Pharmacokinetics of Granulocyte-Macrophage Colony-Stimulating Factor
NH&MRC Practitioner Fellowship, National Health & Medical Research Council, Australia, 2008