I am a cell biologist with a primary interest in understanding how our cells safeguard the integrity of the proteins they manufacture, a process known as protein quality control.
Eukaryotic cells carefully orchestrate protein biogenesis, trafficking, localisation, function, degradation and replenishment. In cancer, unfavourable microenvironments and increased biosynthetic demands create cell populations in which protein homeostasis is disrupted, leading to stress conditions normally sufficient to induce cell death. However, cancer cells often hijack and constitutively engage intrinsic, ameliorating stress response mechanisms; they can become more robust to unfavourable conditions and avoid cell death. The protein quality control mechanisms responsible for folding and degradation in the endoplasmic reticulum (ER) make important contributions to both basal and stress-induced capacity of the organelle. Understanding the fundamental mechanisms and essential components that maintain, restore and adapt ER homeostasis in cancer are key research themes of our group.
Post-doctoral work, Stanford University
PhD, University of Chicago
MSc, Tokyo Institute of Technology
BSc, Boston University
NDM Prize Fellowship
CFRI Elizabeth Nash Memorial Fellowship
Rotary International Yoneyama Scholar