T: (858) 534-7808
I am a basic scientist with expertise in yeast genetics, protein biochemistry and proteomics. I am interested in deciphering the regulatory pathways that utilize post-translational protein modifications including phosphorylation, ubiquitination and sumoylation to maintain genome integrity.
Chromosomal defects including chromosomal translocations and aneuploidy contribute to the onset and progression of cancer. Genetic studies have revealed a major role of the ATR/ATM family kinase and the SUMO pathway in preventing these chromosomal defects. We are studying how these pathways are regulated, what their targets are and how their modifications regulate their activities to maintain genome stability, and how mutations of these pathways lead to cancer.
I received my BS (1991) from the University of Science and Technology in China and PhD (1998) from Stanford University. After a postdoctoral training in the University of Seattle and Institute for Systems Biology, I joined the Ludwig Institute for Cancer Research and UCSD in 2002. I am currently an Associate Member of the Ludwig Institute and Professor in Department of Cellular and Molecular Medicine in UCSD. I am involved in teaching graduate students in the Biomedical Science graduate program in UCSD. I also serve on various UCSD committees and am also a member of American Society for Biochemistry and Molecular Biology and Society of Chinese Bioscientists in America.
K22 faculty transition award from NHGRI, 2002