T: (858) 534-7267
I head the Laboratory of Structural Biology at the Ludwig Institute for Cancer Research in San Diego, and am an assistant professor in the Department of Cellular and Molecular Medicine at the University of California, San Diego.
I am trained as a biochemist and structural biologist, and my laboratory’s current research focuses on the protein complexes that organize chromosomes in meiosis, a cell division program that gives rise to specialized reproductive cells called gametes. These protein complexes assemble onto chromosomes and coordinate the complex series of DNA recombination and signaling steps required to properly segregate chromosomes and avoid generating aneuploidy, a major cause of miscarriage and developmental disorders in humans.
I attended the University of Virginia, where I majored in biology and biochemistry (BS, Chemistry, 2000). I attended graduate school at the University of California, Berkeley, where I studied the structure and function of DNA topoisomerases from bacteria and archaea in the laboratory of James M. Berger (PhD 2005). My postdoctoral work was in the lab of Stephen C. Harrison at Harvard Medical School. There, I studied the structure of the yeast monopolin complex, which enforces proper chromosome segregation in meiosis by binding and cross-linking pairs of “sister” chromosomes in the first meiotic division.
NSF Graduate Research Fellow, 2001
Helen Hay Whitney Postdoctoral Research Fellow, 2007
Charles A. King Trust Postdoctoral Research Fellow, 2010
Sidney Kimmel Foundation for Cancer Research Scholar, 2012