I am a biologist interested in understanding the control of gene expression during development and in disease. My expertise is in developing and applying genomic technologies that can allow us to study gene expression at greater resolution (e.g. single-cell RNA-seq) and the computational methods needed to infer gene regulatory mechanisms.
My research is focused on developing methods that enable highly detailed analyses of the active portions of the genome in individual cells, in contrast to most methods that only measure the average behaviors across thousands of cells. Single-cell analyses are particularly relevant to cancer because tumor tissue is heterogeneous and often consists of several types of cells with different (complementing) abilities. We are very interested in determining how cells within a tumor differ from each other, and how the cellular compositions relate to prognosis and treatments. These analyses could pinpoint whether there are rare cells that survive treatments to later give rise to secondary tumors.
My lab has also used the single-cell methodology to study individual cells that break off from a tumor and enter the circulation. These circulating tumor cells are directly related to the spread of tumors, but they often exist in too few numbers to be studied with conventional methods. We have demonstrated that our methods can give molecular insights into these cells' unique abilities, with the aim of using this information to develop novel approaches for treatment.
PhD, Microbiology and Tumor biology center, Karolinska Institute, 2004
Msc, Biomedicine, Karolinska Institute, 2000
EMBO Young Investigator Award, 2012
Sven and Ebba-Christina Hagbergs Prize, 2012