Thomas Perlmann lab

The development of the central nervous system is dependent on signaling that leads to the induction of specifically expressed transcription factors. We are interested in mechanisms important for how stem cells develop into specific neuron types. Our research is centered on transcription factors and signaling pathways involved in the development and maintenance of dopamine neurons. Understanding how neural stem cells differentiate has implications for cell replacement therapy in Parkinson's disease. Moreover, the elucidation of how normal stem cells differentiate in the developing central nervous system has relevance for the understanding of cancer.