Aristidis Moustakas lab

Our research covers aspects of signal transduction and basic tumor biology. We specialize in the Transforming Growth Factor β (TGFβ) pathway and aim to decipher mechanisms of cell polarity regulation by the tumor suppressor kinase LKB1. By studying the developmental process of epithelial-mesenchymal transition (EMT) we are trying to understand the basic mechanisms of tumor metastasis and cancer stem cell biology.