Ludwig Oxford’s Skirmantas Kriaucionis writes about the ways DNA base modifications add to the toolkit of critical gene-regulatory mechanisms. He outlines how researchers are just starting to explore how newly recognized epigenetic changes function in the genome.
News and Reports
Ludwig scientists around the world are continually making discoveries that alter our understanding of cancer. Our science is featured in the most prestigious journals and in general media. Explore some of our most recent findings, news and reports.
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Ludwig in the news
A recent study led in part by Ludwig Johns Hopkins Co-director Bert Vogelstein argues that random “mistakes” dividing cells make when copying their DNA account for nearly two-thirds of the mutations that cause cancer. This article, which includes input from Vogelstein, explains the methodology of the study and the implications of its findings.
Ludwig MIT scientist Tyler Jacks discusses recent advancements, market potential and ethnical questions related to CRISPR, a revolutionary gene-editing technology that has changed the cancer research landscape. Jacks and his lab have pioneered the use of CRISPR to construct in vivo models of human cancers.
Ludwig scientists speak about a blood-based screening test they’re developing to measure the a patient's risk of colon cancer recurrence after surgery and determine whether subsequent chemotherapy is advisable. "This study shows that when we find tumor DNA circulating in the blood of cancer patients, recurrence is very likely," says Nickolas Papadopoulos of Ludwig Johns Hopkins.
Cancer Research UK
Ludwig scientists have shown that fragments of tumor DNA circulating in the blood can be used to better gauge the risk of colorectal cancer recurrence and the necessity of chemotherapy following surgery. Cancer Research UK reports that these findings could one day help doctors to better monitor and tailor treatments for their patients.
STAT's Signal podcast
Ludwig MIT's Tyler Jacks shares his expertise about cancer genome complexity in a podcast about cancer, “ninja of the disease world."
The ASCO Post
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