Researchers led by Ludwig MSK's Taha Merghoub reported how a targeted drug can reverse the effects of certain immune cells that suppress responses to cancer immunotherapy. "We can now potentially identify patients whose tumors possess immune suppressor cells and add a drug to their treatment regimen to specifically disarm them," Merghoub tells GEN.
News and Reports
Ludwig scientists around the world are continually making discoveries that alter our understanding of cancer. Our science is featured in the most prestigious journals and in general media. Explore some of our most recent findings, news and reports.
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Ludwig in the news
A team co-led by Sangeeta Bhatia, researcher at Ludwig MIT, engineered strains of Salmonella bacteria to produce three types of cancer-killing drugs. The Atlantic reported on their findings, which show that, when used in combination with chemotherapy, the engineered bacteria can induce dramatic regressions of aggressive colon tumors.
A new Nature study co-authored by Irv Weissman, director of Ludwig Stanford, found that the “don’t eat me” signal many tumor cells display on their surfaces to evade immune system attack - called CD47 - also appears to play a role in enabling atherosclerosis, the process underlying heart attacks and strokes. Stanford’s Scope blog explains the significance of these findings.
Ludwig scientists speak about a blood-based screening test they’re developing to measure the a patient's risk of colon cancer recurrence after surgery and determine whether subsequent chemotherapy is advisable. "This study shows that when we find tumor DNA circulating in the blood of cancer patients, recurrence is very likely," says Nickolas Papadopoulos of Ludwig Johns Hopkins.
Cancer Research UK
Ludwig scientists have shown that fragments of tumor DNA circulating in the blood can be used to better gauge the risk of colorectal cancer recurrence and the necessity of chemotherapy following surgery. Cancer Research UK reports that these findings could one day help doctors to better monitor and tailor treatments for their patients.
Forty Seven, a clinical-stage immuno-oncology company founded by Ludwig Stanford director Irv Weissman, announced that it has completed the first half of a $75 million financing round and has licensed the rights to multiple immuno-oncology programs from Stanford University.
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The Washington Post