Huilin Zhou lab

A hallmark of cancer is genome instability caused by DNA replication errors ranging from point mutations to chromosomal rearrangements, which drive the evolution of cancer. The goal of the Zhou lab is to understand how faithful DNA replication is achieved, how its dysfunction causes chromosomal rearrangements, and how we could exploit the Achilles heel of genome instabilities for cancer diagnosis and treatment. At the heart of chromosomal DNA replication is the DNA replisome, a large macromolecular machine that performs genome duplication and is regulated by several signal transduction pathways including the SUMO pathway and the DNA damage checkpoint. Using Saccharomyces cerevisiae as a model system, we are investigating how these regulatory pathways work, how they control DNA replication and how DNA replication is spatially and temporally coupled to chromosome dynamics.