Tumors are sophisticated communities of cells–cancerous and otherwise–that function together to sustain and propagate malignancy. Studying the aberrations and adaptations of cancer cells often requires the integration of multiple subspecialties of cancer research. Many Ludwig researchers do just that to capture the subtleties of tumor growth, survival, metastasis and resistance to therapy. They chart the signaling networks within cells that alter their growth, and the metabolic adaptations that sustain proliferation. They analyze the genomic and subcellular processes that turn a settled cell into a metastatic one, and the biochemical changes that help cancer cells thrive in the harsh, oxygen and nutrient-poor recesses if the tumor. These and a host of other studies are often blended to paint an increasingly nuanced picture of cancer biology, one that is of immeasurable value to the design of new diagnostics and therapies.