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Earlier detection of cancer

Ludwig Johns Hopkins Co-director Ken Kinzler gives an overview of his team’s latest work on the early detection of cancer and discusses both the opportunities and challenges of detecting cancer earlier.

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Normalizing the tumor microenvironment to improve immunotherapy of cancer

Ludwig Harvard investigator Rakesh Jain discusses how the abnormal tumor vessels and matrix create a hostile microenvironment that fuels tumor progression and confers resistance to conventional and emerging cancer treatments.

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Utilizing molecular imaging technologies to predict, monitor and optimize immunotherapies

Sam Gambhir, the Virginia and D. K. Ludwig Professor of Cancer Research at Stanford University School of Medicine, gives an overview of molecular imaging technologies and how they are being utilized to monitor immunotherapies in living subjects.

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Strategies to investigate and target the tumor microenvironment

Johanna Joyce introduces the general features of the tumor microenvironment;, discusses critical functions of tumor-promoting myeloid cells in regulating cancer progression, metastasis and therapeutic resistance; and outlines current strategies for therapeutic targeting.

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Clinical research in an era of disease-agnostic basket trials

George Demetri discusses the next generation of pathway-targeting therapies being tested against many cancer types and how clinical trials can be designed to optimize collaboration between lab-based researchers and clinical scientists, generating new insights into cancer sensitivity and resistance to therapy.

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Convergence of the circadian clock and cancer

Ludwig Scientific Director Chi Van Dang has worked to unravel how the oncogene MYC links the aberrant metabolism of cancer cells to their unchecked proliferation.

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Scale and complexity of hypoxia signaling pathways and their implications for cancer

Peter Ratcliffe outlines the HIF hydroxylase pathway, discusses its evolution and considers its operation in health and disease.

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Oxford symposium highlights

Here’s a brief highlights video of the symposium held in Oxford in September 2017 to celebrate the 10th anniversary of the Ludwig Oxford Branch.


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A tribute to Joan Brugge

Joan Brugge was recently awarded the American Cancer Society Medal of Honor. Learn more about Dr. Brugge in this video tribute to her life and research, courtesy of ACS.


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The circuitry of metastasis

Ludwig’s Robert Weinberg discusses his laboratory’s extensive investigation of a complex cell-biological program known as the epithelial-mesenchymal transition (EMT). In carcinomas, EMT results in the acquisition of multiple traits associated with high-grade malignancies.

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Precision medicine: What is missing from the current initiatives?

Ludwig’s Bing Ren provides an overview of current large-scale efforts to uncover functional elements of the human genome using new technologies.

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Understanding blood vessel growth

The body contains many different types of blood vessels. Sarah De Val’s lab at Ludwig Oxford is trying to understand the processes that control the growth of each type of blood vessel in order to develop better ways to manipulate them.


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An introduction to how the development of different types of blood vessel is regulated, by the De Val group at the Ludwig Institute for Cancer Research, University of Oxford.

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Stanford stem-cell researchers

Kyle Loh, PhD, describes research on ways to guide stem cell development in order to create any kind of cell in the body. In research being published this week, Loh and his colleagues in Irving Weissman’s lab at Stanford describe a method for converting stem cells into human bone and heart tissue.


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1462147200
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Giants in Baltimore

Ludwig Johns Hopkins Co-Directors Bert Vogelstein and Ken Kinzler sit down with JCI for their ‘Conversations with Giants in Medicine’ series to discuss their backgrounds, what inspired them to be cancer researchers and their goals as scientists.

Bert Vogelstein, MD, and Kenneth Kinzler, PhD, are codirectors of the Ludwig Center at the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine. Vogelstein and Kinzler demonstrated that colorectal cancer results from the sequential accumulation of mutations in oncogenes and tumor suppressor genes, establishing a paradigm for modern cancer genomics. Additionally, they discovered the tumor suppressors APC and TP53; they were the first to perform exomic sequencing in tumors; and they developed digital PCR. In an interview with JCI’s Editor-at-Large Ushma Neill, Vogelstein and Kinzler reflect on their career trajectories and past discoveries and discuss their goals as scientists.


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George Demetri on sarcoma

George Demetri describes developments in sarcoma research that are contributing to advances in the development of targeted and epigenetic drugs, and even immunotherapies.


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How cells clean up proteins

Oxford’s John Christianson describes the relevance of his studies on how cells recognize and clean up misfolded proteins, and how those processes might be targeted by therapies for cancer and other diseases.


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Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. Better knowledge of these mechanisms helps us understand the root cause of different kind of diseases, and also develop targets for therapeutic intervention.

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Pharmacogenomics

Ludwig Oxford’s Sebastian Nijman discusses his development of isogenic—or genetically uniform—cell lines to study how drugs interact with the variegated genetic landscape of malignant tumors, and their application to analyze drug resistance and identify surprising candidate drug targets major cancers.

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Immunomodulation of the tumor microenvironment

Benoît Van den Eynde tells the story of this discovery and its subsequent translation to develop a pair of candidate immunotherapies, one of which will soon enter clinical trials in partnership with Pfizer.

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Pathways to Carcinogenesis: Stem cells, progression and the rogue cell’s ‘Don’t eat me’ signal​​

Irv Weissman of Ludwig Stanford covers his laboratory’s investigation of cancer stem cells with an emphasis on CD47.

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Unraveling glioblastoma’s resistance

Web Cavenee (a cancer geneticist), Frank Furnari (a cancer biologist) and Paul Mischel (a cancer pathologist) of Ludwig San Diego describe their joint investigation of glioblastoma over the past several years.

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Strategies for winning the wars on cancer

Ludwig Johns Hopkins Co-director Bert Vogelstein speaks about what the past four decades of research has taught us about the mechanics of cancer, what genomics and molecular biology have taught us about it and how all of this information might best be exploited to address the challenges posed by cancer.

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Inside the San Diego Branch

In this video by The American Society for Cell Biology, Ludwig San Diego scientists describe how their studies in cell biology advance cancer research.


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Sir David Lane at MSK

Ludwig Scientific Director Sir David Lane visits MSK to chat with young scientists.

Ludwig’s Scientific Director Sir David Lane has met and spoken with many gifted researchers at Ludwig laboratories around the world. On a recent trip to New York, he chatted with a group of young scientists at the Ludwig MSK Center and Collaborative Laboratory about everything from our organization’s contributions to immunotherapy to beginning a career in the biomedical sciences. Here’s the first installment of what we expect will be an ongoing video dialogue.

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Immune system vs. cancer

Treat the person AND the cancer.” In this TEDxTimesSquare talk, Jedd Wolchok gives a straightforward explanation of immunotherapy and its importance.


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This talk was given at a local TEDx event, produced independently of the TED Conferences. When you hear of a leader changing the way millions of people look at a problem. Especially a problem like cancer, then you know they are pushing boundaries. As Chief of Melanoma and Immunotherapy at Memorial Sloan Kettering, Dr. Wolcchok is the lead Investigator looking at ways to unlock the Immune System to fight cancer.

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Sir David Lane at Oxford

Ludwig Scientific Director Sir David Lane answers questions from postdoctoral research fellows at the Ludwig Oxford Branch.


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Genome-wide transcriptomic analyses of single cells

The comprehensive capture of all RNA species present inside a single cell has been a long-standing goal of biology.

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Therapeutically exploiting cytokines that link inflammation to tumor progression

Ludwig Melbourne scientist Matthias Ernst speaks about his research on therapeutically exploiting cytokines that link inflammation to tumor progression, including insights he has gained from mouse models used to mimic gastrointestinal tumorigenesis in the presence and absence of chronic inflammation, and the potential for interleukin-11 signaling as a therapeutic target.

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