I study the role of chromatin regulation in human cancer, with a focus on the structure and function of the mammalian SWI/SNF (or BAF) family of chromatin remodeling complexes, which are mutated in more than a fifth of human cancers. My lab has elucidated the molecular mechanisms that drive human synovial sarcoma, linking the hallmark feature of these cancers—the aberrant SS18-SSX fusion protein—to BAF complex dysfunction and the development of cancer. We are also developing therapies for cancers driven by BAF mutations.
I am an Assistant Professor of Pediatric Oncology at the Dana-Farber Cancer Institute and Harvard Medical School and a Member of the Broad Institute of MIT and Harvard. I earned my Ph.D. in Cancer Biology from the Stanford University School of Medicine, and have received the NIH Director’s New Innovator Award, the Pew-Stewart Scholar in Cancer Research Award, and was named one of Forbes Top 30-under-30 in Science and Medicine.
Ludwig Center at Harvard
450 Brookline Avenue
Boston, Massachusetts, U.S. 02215
T 617 632 3985
F 617 632 3408