As a physician-scientist, I lead a systems hematology laboratory at Stanford and direct a clinical practice focused on myelodysplastic neoplasms and clonal hematopoiesis. My research group studies hematopoiesis—the complex process by which hematopoietic stem cells generate the diverse blood cells essential for health throughout life. Our mission is to understand how individual blood cells change during aging and cancer development, with particular focus on how dysregulation of this process leads to cytopenias and hematologic malignancies.

We integrate expertise spanning clinical medicine, functional hematology, molecular and cellular biology, genomics, bioinformatics, and machine learning. By combining advanced experimental techniques with computational approaches, we examine blood cell development and function at single-cell resolution. Our work aims to identify the earliest cellular changes in cancer development, map how stem cells interact within their tissue environments and develop AI-powered tools that predict stem cell behavior and disease progression. Our goal is to translate these efforts into improved diagnostics and precision therapeutic strategies for patients with blood disorders and malignancies.