Ernst Lengyel
Tumor biology, Tumor microenvironment


MD, PhD, University of Munich

Residency, University of Munich

Gynecologic OncologyFellowship, UCSF/Stanford

I am a clinical gynecologic oncologist who is board certified in general gynecology and gynecologic oncology and am the Arthur L. and Lee G. Herbst Professor of Obstetrics and Gynecology and Chair of the Department of Obstetrics and Gynecology at the University of Chicago. I attended medical school at the University of Munich and completed my postgraduate clinical training there as well as the University of California, San Francisco, and Stanford University. In 2003, I joined the faculty of the University of Chicago. Since then, I have established a clinical practice specializing in radical debulking surgery for ovarian cancer and a translational research laboratory focused on understanding ovarian cancer biology. Recently, my group elucidated how adipocyte and fibroblast cancer cell interactions promote ovarian cancer metastasis through the metabolic reprogramming of tumor cells. We have also shown that mesothelial cells play a critical role in ovarian cancer metastasis. My laboratory uses high-throughput screening technology to find novel drugs for the treatment of ovarian cancer. I have published over 100 peer-reviewed papers, including contributions to Nature, Nature Medicine, Cell, Cell Metabolism, Cancer Discovery and JCI. I am the author of the chapter on ovarian cancer in the current edition of Principles and Practice of Gynecologic Oncology, the standard textbook of the specialty.


Ludwig Center at the University of Chicago
5758 South Maryland Avenue MC 9006
Chicago, Illinois, U.S. 60637

T 773 702 0817
F 773 834 7233


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