I am a Professor of Computational Biology at the Dana-Farber Cancer Institute, and at the Harvard T.H. Chan School of Public Health. My laboratory investigates the evolutionary dynamics of cancer initiation, progression, response to therapy and the emergence of drug resistance. We study the genetic and epigenetic changes that drive cancer, the order of oncogenic mutations that initiate and sustain tumorigenesis and the “hows and wheres” of these processes.

I completed my undergraduate training in mathematics and molecular biology from the University of Vienna, Austria, and my Ph.D. from the Department of Organismic and Evolutionary Biology at Harvard University, after which I was awarded a fellowship from the Harvard Society of Fellows. From 2007 to 2010, I was an Assistant Professor in the Computational Biology Program at Memorial Sloan-Kettering Cancer Center. I am now the Director of the Dana-Farber Cancer Institute Physical Sciences-Oncology Center and the Center for Cancer Evolution. I have received, among other honors, the Theodosius Dobzhansky Prize of the Society for the Study of Evolution, the Alice Hamilton Award from Harvard University, and the Vilcek Prize for Creative Promise in Biomedical Science.