A new player in regulation of immune signaling

A new study in Molecular Cell by the group of Mads Gyrd-Hansen and their collaborators in Cambridge, UK, adds a new piece to the complex jigsaw of proteins that regulate immune signaling. They show how a protein called SPATA2 is crucial for regulation of ubiquitination—a process that links small protein ‘blocks’ together to form molecular signals—by bringing together enzymes that add and remove ubiquitin.


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