The Oxford Branch studies signaling pathways that influence cancer initiation and progression, with a focus on infection, inflammation and cancer epigenetics. We aim to advance cancer prevention, early diagnosis and effective treatment.
Ludwig Oxford approaches the problems of cancer biology from several different angles. Our research program explores cancer susceptibility, initiation, progression, metastasis and resistance to therapy, and includes technical expertise essential to the development of novel clinical and research technologies—such as computational modeling and chemical biology. Over all, our specific areas of interest include the study of tumor heterogeneity and the regulation of gene expression, reflecting our interests in genetics, epigenetics, the tumor microenvironment, cell signaling and gene expression. Our branch has recently launched a multidisciplinary research program focused on upper gastrointestinal cancers, with the aim of developing novel approaches to preventing, diagnosing and treating such malignancies. Our laboratories are housed in the Old Road Campus Research Building, and we are affiliated with the Nuffield Department of Medicine at the University of Oxford.
Ludwig Cancer Research is an international collaborative network of acclaimed scientists that has pioneered cancer research and landmark discovery for nearly 50 years. Ludwig combines basic science with the ability to translate its discoveries and conduct clinical trials to accelerate the development of new cancer diagnostics and therapies. Since 1971, Ludwig has invested $2.7 billion in life-changing science through the not-for-profit Ludwig Institute for Cancer Research and the six U.S.-based Ludwig Centers.
Scientists at the Oxford Branch of the Ludwig Institute for Cancer Research focus on a variety of subjects of importance to cancer research. These range from intracellular signaling, genomics and epigenetics to tumor immunology, oxygen sensing and angiogenesis. With stable core funding from Ludwig Cancer Research and access to state-of-the-art facilities in the renowned academic environment of the University of Oxford at the Old Road Research Campus, our PIs have both the opportunity and means to pursue groundbreaking basic and translational scientific research.
Postdoctoral Research Scientist – Inflammation and cancer
Nuffield Department of Medicine (NDM), Ludwig Institute for Cancer Research and Oxford Big Data Institute, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, UK.
Grade 7: £32,817- £40,322 p.a.
Only online applications received by 12:00 PM (noon, UK time), March 30, 2020, will be considered.
Ludwig Oxford seeks an exceptional and motivated postdoctoral research scientist to study the role of the cellular ubiquitin machinery in inflammation and cancer in vivo. The research in Professor Mads Gyrd-Hansen’s group at the Oxford Branch of the Ludwig Institute for Cancer Research focuses on understanding how the ubiquitin system controls innate immune processes that protect against infectious agents but, when inappropriately activated, also contribute to chronic inflammation and cancer. The long-term goal of the work is to identify molecular processes that can be targeted pharmacologically to treat inflammation-driven pathologies, including cancer.
The successful applicant will have a PhD in immunology, infection biology or a related discipline, a background in cancer biology and experience in experimental murine models and will design and perform original research using in vivo models and mammalian cell culture systems. It is essential that the applicant be able and willing to travel to carry out parts of the project at a research institution in the European Union. More details about the position and its associated responsibilities are available here.
This post is offered full-time on a 2-year fixed-term contract funded by a Wellcome Trust Fellowship.
Applications must be made online by 12:00 noon (BST) on March 30, 2020.
Ludwig Institute for Cancer Research, Oxford
Nuffield Department of Clinical Medicine
Old Road Campus Research Building
off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
T +44 (0) 1865 617507