The Oxford Branch studies signaling pathways that influence cancer initiation and progression, with a focus on infection, inflammation and cancer epigenetics. We aim to advance cancer prevention, early diagnosis and effective treatment.
Ludwig Oxford approaches the problems of cancer biology from several different angles. Our research program explores cancer susceptibility, initiation, progression, metastasis and resistance to therapy, and includes technical expertise essential to the development of novel clinical and research technologies—such as computational modeling and chemical biology. Over all, our specific areas of interest include the study of tumor heterogeneity and the regulation of gene expression, reflecting our interests in genetics, epigenetics, the tumor microenvironment, cell signaling and gene expression. Our branch has recently launched a multidisciplinary research program focused on upper gastrointestinal cancers, with the aim of developing novel approaches to preventing, diagnosing and treating such malignancies. Our laboratories are housed in the Old Road Campus Research Building, and we are affiliated with the Nuffield Department of Medicine at the University of Oxford.
|We are seeking to appoint a Scientific Data Manager to join the Ludwig Institute at the Nuffield Department of Medicine.
As the Scientific Data Manager, you will put systems in place to deal with the current challenge of managing data and metadata. This will involve the development of a metadata storage database and managing data transfer, and the security and governance of data. You will help to implement and further develop the Ludwig Information Governance and Security strategy. As part of this, you will also help to develop a system to gather and store metadata for data generated by and held within the Ludwig Institute. You will be supported by the wider administrative team at the Ludwig, as well as by our in-house data processing team, and you will work closely with computational scientists at the Institute, and foster links to the experimental groups that are generating the data.
It is essential that you hold a degree in a relevant subject such as biology or another quantitative science. You will have experience of Information Governance in a clinical or research setting and have previous experience with large-scale data management, preferably in a research environment.
You will have excellent communication and organization skills, a positive ‘can do’ attitude and a service-oriented approach to interactions with others.
This position is offered full time on a fixed term contract for 3 years and is funded by Ludwig.
Applications are to be made online by 12.00 noon (UK time) on Tuesday 4 April 2023.
|We are seeking to appoint a highly motivated Postdoctoral Researcher to join the team at the Ludwig Cancer Research Oxford Branch.
You will be supervised by Professor Yang Shi at Ludwig Cancer Research and work closely with a medicinal chemist. Your primary responsibility will be to purify recombinant proteins and set up in vitro assays for the RNA enzymes as well as a panel of additional enzymes as negative/selectivity controls to identify small molecules that have on-target activities towards intended RNA enzymes. You will also develop cell-based activity assays and, if possible, in vivo models to evaluate the efficacy of the compounds. You will design and perform original research and manage your own academic research and administrative activities which will include small scale project management, and the coordination of multiple aspects of work to meet deadlines.
It is essential that you hold a PhD (or close to completion) in Biochemistry or Cell Biology, and have a strong biochemical, molecular and cell biological background. Demonstrable experience in assay development and in analysing small molecules in vitro and in vivo is essential, as well as the ability to manage your own academic research and associated activities. You will have a good publication record, including experience in independently writing scientific reports and manuscripts, and be well organised with the ability to adapt to changing project priorities.
This position is offered full time on a fixed term contract for 3 years and is funded by the Department.
Applications must be made online by 12.00 noon (UK time) on Tuesday 11 April 2023.
Ludwig Institute for Cancer Research, Oxford
Nuffield Department of Clinical Medicine
Old Road Campus Research Building
off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
T +44 (0) 1865 617507