The Oxford Branch studies signaling pathways that influence cancer initiation and progression, with a focus on infection, inflammation and cancer epigenetics. We aim to advance cancer prevention, early diagnosis and effective treatment.
Ludwig Oxford approaches the problems of cancer biology from several different angles. Our research program explores cancer susceptibility, initiation, progression, metastasis and resistance to therapy, and includes technical expertise essential to the development of novel clinical and research technologies—such as computational modeling and chemical biology. Over all, our specific areas of interest include the study of tumor heterogeneity and the regulation of gene expression, reflecting our interests in genetics, epigenetics, the tumor microenvironment, cell signaling and gene expression. Our branch has recently launched a multidisciplinary research program focused on upper gastrointestinal cancers, with the aim of developing novel approaches to preventing, diagnosing and treating such malignancies. Our laboratories are housed in the Old Road Campus Research Building, and we are affiliated with the Nuffield Department of Medicine at the University of Oxford.
Grade 7: £32,817 – £40,322 per annum with discretionary range to £44,045
Applicants are invited for the position of Postdoctoral Scientist in Hypoxia Biology to work on the biology of syndromic kidney cancer within the Oxford Hypoxia Biology Laboratory led by Professor Sir Peter Ratcliffe, which is part of the Oxford Branch of the Ludwig Institute for Cancer Research.
You will join a team that is investigating familial kidney cancer syndromes; in particular von Hippel-Lindau (VHL) disease and hereditary leiomyomatosis and renal cancer (HLRCC), which are caused by mutations in the von Hippel-Lindau ubiquitin E3 ligase (pVHL) and Krebs Cycle enzyme fumarate hydratase (FH), respectively.
You will have a doctoral degree in a relevant discipline with experience in molecular and cellular biology. The work is problem orientated and will encompass a range of techniques as scientifically appropriate, including the development, validation and analysis of cellular and animal models and the study of human material. Specific training and experience will be provided in both in situ analyses of tissue and in single-cell genomic analyses.
Applications must be made online by 12.00 noon on Wednesday 22nd July 2020.
For social media:
Vacancy in Sir Peter Ratcliffe’s lab at Ludwig @UniofOxford for a post-doc specialising in hypoxia biology to work on familial kidney cancer syndromes. Apply by July 22nd https://bit.ly/3igE4ya
Ludwig Institute for Cancer Research, Oxford
Nuffield Department of Clinical Medicine
Old Road Campus Research Building
off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
T +44 (0) 1865 617507