Ludwig Cancer Research extended a warm welcome in August to Marketa Tomkova, who joined the Ludwig Oxford Branch as a Leadership Fellow. Marketa joins us from the University of California, Davis, where she was a postdoctoral researcher working jointly in the labs of David Segal and Fereydoun Hormozdiari. She is leading her first independent research program at Ludwig Oxford, focused on computational cancer genomics. After training in computer science, Marketa became interested in applying her expertise to important questions in biology and medicine. Marketa has secured funding from the Wellcome Trust and Cancer Research UK to investigate the role of DNA polymerase errors in mutational processes and continue her development of sequencing-based tools for the detection of non-clonal mutations, mismatched base pairs and DNA damage in single molecules. Her work at Ludwig Oxford is at the interface of technological development, epigenomics and mutagenesis, and she will collaborate closely with other groups to develop computational methods to better analyze sequencing data and investigate the role of RNA modifications in cancer initiation and progression. Marketa will also apply cancer genomics, deep learning and interdisciplinary approaches to study how various DNA polymerases contribute to distinct mutational processes and develop methods to detect new drivers of cancer.
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