How cells clean up proteins
Oxford’s John Christianson describes the relevance of his studies on how cells recognize and clean up misfolded proteins, and how those processes might be targeted by therapies for cancer and other diseases.
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Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. Better knowledge of these mechanisms helps us understand the root cause of different kind of diseases, and also develop targets for therapeutic intervention.