Gilead announced that it has struck a deal to buy Forty Seven for $4.9 billion. Forty Seven, a biotechnology company, was created in 2015 to build on evidence of the role of CD47 in immune evasion that Ludwig Stanford’s Irv Weissman and his colleagues generated.
To design more broadly effective immunotherapies, researchers have been looking for additional immune cell types beyond T cells to mobilize against cancer. In a new Nature study, Ludwig MSK’s Taha Merghoub and his MSK colleague Vinod Balachandran report the discovery of just such a candidate: Group 2 innate lymphoid cells (ILC2s).
Ludwig Lausanne’s Ping-Chih Ho and colleagues have identified a mechanism by which regulatory T cells adapt their metabolism to thrive in the harsh microenvironment of the tumor. They report in Nature Immunology that the mechanism is exclusively engaged by regulatory T cells (Tregs) that reside in tumors and that its disruption boosts the effects of cancer immunotherapy in a mouse model of melanoma.
Michel Detheux co-founded iTeos Therapeutics, a clinical stage biopharmaceutical company focused on developing cancer immunotherapy treatments, in 2012 with Ludwig’s Benoit Van den Eynde. During this interview, Detheux discusses, among other things, iTeos’ partnership with Ludwig and how the research Ludwig funded became the foundation of iTeos.
A Ludwig Cancer Research study has devised a new type of chimeric antigen-receptor (CAR) T cell that can be switched on and off on demand. The study, led by Melita Irving of the Lausanne Branch of the Ludwig Institute for Cancer Research, George Coukos, director of the Branch, and their colleague Bruno Correia of the École Polytechnique Fédérale de Lausanne (EPFL), addresses a central conundrum of CAR-T therapies: their tendency to provoke potentially deadly runaway immune responses against healthy tissues in patients.
Vaccitech Oncology Limited (VOLT), a strategic collaboration of the Ludwig Institute for Cancer Research and the biotech Vaccitech, has entered into a clinical partnership with Cancer Research UK to develop VOLT’s VTP-600 immunotherapy as a treatment option for patients with non-small cell lung cancer (NSCLC).