Ludwig Princeton’s Yibin Kang has discovered a new compound that disables a protein, metadherin, that plays a role in many major cancers. The compound is currently in preclinical development for evaluation in human trials.
In this video interview, Ludwig Princeton’s Yibin Kang discusses his research on the MTDH gene, its central role in cancer metastasis and how he and his colleagues are targeting the gene.
A study led by Ludwig Harvard’s Stephen Elledge employed CRISPR to probe the effects of mutations to thousands of genes in cancer. The study, published in Science, discovered in mouse models that mutations to more than 100 tumor suppressor genes prevent the immune system from detecting and destroying cancer cells.
A study led by Ludwig MIT’s Tyler Jacks, published in Cell, showed that vaccinating against a subset of cancer antigens generated by random mutations, or neoantigens, can boost the killing of cancer cells by reawakening dormant T cells that target those neoantigens in mice bearing lung tumors.
Ludwig Oxford’s Benoit Van den Eynde and Carol Leung, in collaboration with the labs of Oxford’s Adrian Hill and Irina Redchenko, led a study published in the Journal for ImmunoTherapy of Cancer on a new therapeutic cancer vaccine regimen. The regimen, which includes the vector used in the Oxford-AstraZeneca COVID-19 vaccine and is equipped with two cancer antigens discovered and developed by Ludwig researchers, drives the infiltration of cancer-killing T cells into tumors.
Italian newspaper La Repubblica interviewed Ludwig Lausanne’s George Coukos about breast cancer and Lausanne’s new cellular therapy trial.
Ludwig MIT’s Sangeeta Bhatia led a study, published in Nature Materials, which assesses a multimodal nanosensor that noninvasively reveals the presence of cancer-associated proteins through a urine test and pinpoints tumors’ locations via PET imaging.
Ludwig Lausanne’s Douglas Hanahan spoke with Oncology Times about his recently published research in Cancer Discovery. The study identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert to a progenitor state of cellular development to spawn highly aggressive tumors. These tumors are capable of metastasis to the liver and lymph nodes.
Ludwig San Diego’s Beata Mierzwa was honored as a female STEM leader by Lyda Hill Philanthropies’ IF/THEN Initiative, which opened in Dallas, Texas in May 2021.
Ludwig Scientific Director Chi Van Dang and co-authors note in this essay that the Cancer Moonshot program, launched under the leadership of then Vice President Biden, has made significant progress, though major challenges remain.
During Week 1 AACR Annual Meeting 2021, Ludwig Princeton’s Josh Rabinowitz spoke about his ongoing studies on whether ketogenic diets can slow tumor growth.
The Ludwig Institute for Cancer Research established a branch at Princeton University that will be wholly dedicated to the study of cancer metabolism and the translation of its findings into new paradigms for cancer prevention and treatment.
Ludwig Cancer Research announced on its 50th anniversary the launch of the newest branch based at Princeton University which will be wholly dedicated to the study of cancer metabolism and the translation of its findings into new paradigms for cancer prevention and treatment.
Ludwig Cancer Research announces the launch of its newest Branch, based at Princeton University and wholly dedicated to the basic and translational study of cancer metabolism.
In this interview with Endpoint News, Ludwig MIT’s Sangeeta Bhatia speaks about gender inequality in the biotechnology industry.
To commemorate International Women’s Day, Ludwig scientist Johanna Joyce spoke about the healthy “microenvironments,” with supportive mentors and successful female professors, that she encountered in her journey through academia.
Linda Bauld, who chairs a session at the upcoming Cancer Prevention – Physical Activity conference convened by Ludwig Cancer Research and Cancer Research UK, spoke on the importance of exercise as a cancer prevention tool.
Ludwig Lausanne Director George Coukos discusses the Branch’s work, the impact the pandemic has had on research and the hope he has for the effectiveness of second generation TIL therapies. This article is in French.
Ludwig Lausanne Director George Coukos spoke with 24Heures about the Branch’s program to develop cutting edge immunotherapies, their potential impact and the Branch’s future research projects.This article is in French.
Many scientific leaders and advocates anticipate cancer-related issues will be given high priority in the new Biden Administration. Ludwig Institute Scientific Director Chi Van Dang and others comment on what to expect and what ought to be prioritized in a “Cancer Moonshot 2.0.”