MS, Institute of Biochemical Science, National Taiwan University, 2004-2006
PhD, Department of Pharmacology, University of Minnesota, 2008-2012
Postdoctoral fellow, Department of Immunobiology, Yale University, 2012-2015
Assistant Professor, Department of Oncology, University of Lausanne, 2015-2019
Associate Professor, Department of Oncology, University of Lausanne, 2019-present
I am a cancer immunologist, and my research focuses on immunometabolism in T cells and macrophages. My laboratory also explores how the metabolic crosstalk between cancer cells and tumor-infiltrating immune cells shapes the immunosuppressive microenvironment that helps tumors evade immune clearance. Our ultimate goal is to exploit this knowledge to develop interventions to reprogram the tumor microenvironment, reverse immunosuppression and broaden and boost the efficacy of cancer immunotherapy.
My interests in cancer biology and signaling cascades began during my undergraduate and postgraduate training toward a master’s degree at National Taiwan University and grew over the course of my graduate studies toward a PhD at the University of Minnesota. During my postdoctoral training with Susan Kaech at Yale University, I focused on how T cells utilize aerobic glycolysis to support productive T cell immune responses and demonstrated how cancer cells evade T cell immunosurveillance by depriving infiltrating T cells of glucose, which is consumed in large amounts by malignant cells.
In September 2015, I was recruited as an adjunct Ludwig scientist and tenure-track assistant professor in the Department of Oncology at the University of Lausanne. I was made a tenured associate professor at the University of Lausanne in August 2019 and promoted to Associate Member at the Lausanne Branch of the Ludwig Institute for Cancer Research in January 2020.
My work is establishing a fundamental understanding on how tumor cells evade immunosurveillance through their metabolism, and how we can preprogram the metabolic machinery of immune cells to improve immunotherapy. My work is also delineating links between metabolic processes, signaling cascades and epigenetic programming in the activation and differentiation of T cells and macrophages.
I have been fortunate to receive several awards, including the Swiss Bridge Award, Anna Fuller Award, Cancer Research Institute-CLIP investigator award, Melanoma Research Alliance-SITC Young investigator Award and a European Research Council Starting Grant. I was recently named a member of the European Molecular Biology Organization’s Young Investigator Programme. I am also a member of the editorial board of the journal Immunometabolism.
Ludwig Institute for Cancer Research, Lausanne
Agora Research Center
Rue du Bugnon 25A, CH-1005 Lausanne
T (41) 21 545 10 77
F (41) 21 692 59 95