Life-changing
science

At every step of the research process from the lab to the clinic, we are pursuing innovative ways to prevent and control cancer.

How pancreatic tumors thwart an iron-driven demise

Researchers led by CEO and Scientific Director of the Ludwig Institute for Cancer Research Chi Van Dang and Maimon Hubbi, a postdoc in his laboratory at Johns Hopkins University, detail the mechanisms by which two defining features of the pancreatic tumor microenvironment—the composition of metabolites in the fluid around the cancer cells and severe oxygen deficiency in the tumors—converge to counter a type of cell death called ferroptosis, suggesting new strategies for the treatment of advanced pancreatic cancer.

Magazine

Researchers led by Ludwig Oxford’s Richard White and Miranda Hunter of the Memorial Sloan Kettering Cancer Center have discovered that the tight physical confinement of tumor cells by surrounding tissues has epigenetic consequences that can influence melanoma progression. Rather than continuing to divide rapidly, squeezed cancer cells in such circumstances activate a program of ‘neuronal invasion’ and spread into neighboring tissues. Aside from fleeing, confined melanoma cells also build a cytoskeletal cage (yellow) around their nuclei (blue) that helps protect the nucleus from rupture and DNA from damage caused by confinement-induced stress.

The April 2026 issue of Ludwig Link has a huge collection of research briefs, news of a new Ludwig lab at Weill Cornell and a new colleague at Ludwig Oxford, snapshots from the Harvard Center’s retreat and a brief remembrance of Ludwig MIT’s Richard Hynes, who passed away in January.

Ludwig launches a new lab

George Coukos, Ludwig Cancer Research

The Ludwig Laboratory for Cell Therapy will be led by George Coukos, former founding director of the current Lausanne Branch of the Ludwig Institute.

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Book cover of A vision Realized: The story of Ludwig Cancer Research

A Vision Realized: The story of Ludwig Cancer Research

Learn in this brief history about the creation of the Ludwig Institute, the establishment of the Ludwig Centers, how they work together to solve the puzzle of cancer—and the enigmatic, endlessly creative shipping titan who bequeathed his sprawling conglomerate to the whole endeavor.

How an energy crisis drives T cells to exhaustion in tumors
Ludwig scientists are co-recipients of prestigious Cancer Grand Challenges award
One immune variable predicts poor outcomes across tumor types and species
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