Ludwig Cancer Research

Targeting the matrix for anti-tumor T cell revival

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired—so much so, in fact, that they can even die from exhaustion.

Magazine

This is an intravital 2-photon image of a mouse melanoma ten days post-engraftment, with CD8+ tumor-infiltrating lymphocytes (TILs, orange and red), dendritic cells (green), blood vessels (Qdot, gray), and collagen fibers (second harmonic generation, cyan).

The May 2025 issue of Ludwig Link includes a rich lineup of research briefs, news of an ambitious program on myeloproliferative neoplasms at Ludwig Oxford and the first edition of our new image gallery.

Meet our scientists

Jenny Hogstrom, Quenton Rashawn Bubb and Jacqueline Douglass, Ludwig Cancer Research

Three Ludwig Center trainees took a few minutes out of their very busy schedules to tell us about their lives, scientific fascinations, avocational passions and views on a variety of issues.

A Vision Realized: The story of Ludwig Cancer Research

Learn in this brief history about the creation of the Ludwig Institute, the establishment of the Ludwig Centers, how they work together to solve the puzzle of cancer—and the enigmatic, endlessly creative shipping titan who bequeathed his sprawling conglomerate to the whole endeavor.