Success Stories

Making discoveries

Ludwig has a long history of pioneering cancer discoveries. Today, Ludwig scientists around the world are collaborating on new projects, and on ways to move breakthroughs toward the ultimate goal of patient benefit. These are some of the novel ways Ludwig researchers have teamed up to advance our understanding and control of cancer.

Ping-Chih Ho eavesdrops on the metabolic chatter between cancer cells and immune cells. Manipulating this malignant crosstalk could significantly boost the efficacy of immunotherapy.

Frank Furnari’s sustained exploration of the signaling networks, communications and genetic idiosyncrasies of brain cancer cells is yielding valuable clues to new therapies.

Marcia Haigis has shown how biochemical discord in the powerhouse of the cell can shape the aberrant metabolism of cancer cells. Disrupting the relevant metabolic circuitry could help treat a variety of malignancies.

Benoit Van den Eynde, Ludwig Brussels

Benoît Van den Eynde began his career helping to lay the scientific groundwork for modern immunotherapy. Now he’s unraveling the myriad ways tumors thwart immune attack—and showing how to undo those defenses.

Alexander Rudensky’s decades-long study of the regulatory T cell continues to yield surprises, exposing new ways in which the suppressive immune cells function and how they inhibit and fuel malignancy. His discoveries illuminate powerful new approaches to cancer prevention and therapy.

Johanna Joyce, Ludwig Lausanne

Johanna Joyce’s ongoing investigation of how noncancerous cells in the microenvironment of tumors contribute to malignant growth, drug resistance and metastasis is also revealing how such relationships might be disrupted to treat cancer.

Sanjiv Sam Gambhir

Sam Gambhir’s mission to detect disease early and visualize cells and molecular processes hidden deep within living bodies is transforming cancer diagnosis and therapy.

Judith Shizuru has long dreamt of using stem cells to perform—and transform—bone marrow transplantation. She recently took a big step toward that goal.

Ralph Weichselbaum’s decades-long quest to expand the uses of radiotherapy has exposed its ties to the immune response and yielded a trove of clues to novel cancer therapies.

Sangeeta Bhatia has harnessed an enduring fascination with getting synthetic things to infiltrate and talk to tissues to devise new approaches to diagnosing and treating cancer.